On BIG-IP versions 16.0.x before 16.0.1.1, 15.1.x before 15.1.2.1, 14.1.x before 14.1.4, 13.1.x before 13.1.3.6, and 12.1.x before 12.1.5.3, undisclosed requests to a virtual server may be incorrectly handled by the Traffic Management Microkernel (TMM) URI normalization, which may trigger a buffer overflow, resulting in a DoS attack. In certain situations, it may theoretically allow bypass of URL based access control or remote code execution (RCE). Note: Software versions which have reached End of Software Development (EoSD) are not evaluated.
Use CWE-119, F5 vendor hub and Big-Ip Access Policy Manager product page to widen CVE-2021-22991 into its surrounding weakness, vendor, and product context.
Compare it with CVE-2025-61990, CVE-2025-58071 and CVE-2025-61960 for nearby disclosures in the same product family.